"Every defendant in America is presumed innocent until proven guilty, including Luigi, who, unlike any other defendant, has to fight the same charges twice," she added.
Mangione faces two federal stalking charges resulting in death. Two other charges, murder through the use of a firearm and a weapons charge, were dismissed earlier in 2026. The federal murder charge was death penalty eligible.
The U.S. attorney's office declined to comment when reached by Fox News.
Shortly after informing the court that they plan to pursue a psychiatric defense for Mangione, his lawyers suddenly withdrew the "extreme emotional disturbance" defense plan.
Under New York law, if the claim was accepted by jurors following his conviction, it had the potential to reduce a murder verdict to first-degree manslaughter.
Randolph Rice, a Maryland-based attorney and legal analyst, told Fox News Digital he thinks Mangione changed his mind after realizing this defense could open him up to more issues.
"He might have had a change of heart and said, 'Wait a second, I'm going into state court. I'm admitting that I did this. How is this going to play when I'm facing even more serious charges in federal court in January of next year?'" Rice said.
Criminal defense attorney James Leonard called the initial defense plan "a very risky trial strategy."
"They are basically telling the jury that Mangione committed the murder, but here is why he did it and, because of this, you should nullify his guilt," Leonard said. "If the jury accepts that, it would be an epic win for the defense team. If the jury rejects that, it [would] likely mean that Mangione will spend the rest of his life behind bars."
Fox News Digital's Stepheny Price and Michael Ruiz contributed to this report.