The left-wing streamer said he wants fewer actors like bin Laden to "exist in general."
"The other path of least resistance is to not interfere in these affairs in general and not continue to dominate and create an environment where people are going to seek out revenge and put us in a position of danger," he said.
Piker called the Sept. 11 attacks a "horrifying tragedy" and called them blowback for U.S. actions in the Middle East.
"Blowback is not a justification. Blowback is just what it is," he said. "A justification offers either a moral condemnation or a moral acceptance of the act. I do not accept the act of 9/11 morally".
Piker has faced backlash for remarks in the same interview where he compared the United States to al Qaeda "pound for pound."
"Pound for pound as far as the number of deaths, yes," Piker said. "We have caused tremendous terror all around the world."