Federal authorities on Tuesday charged 10 Southern California defendants in a series of healthcare fraud schemes, including one case involving nearly $270 million in fraudulent Medi-Cal claims and another that allegedly defrauded Medicare out of approximately $27 million.

The charges were part of the Justice Department's broader "2026 National Health Care Fraud Takedown," which resulted in charges against 455 defendants nationwide in schemes involving more than $6.5 billion in alleged fraud.

Acting Attorney General Todd Blanche described the operation as "the greatest combined federal and state effort in combating healthcare fraud in history."

"Fraudsters can no longer rip off American taxpayers," Blanche said during a news conference announcing the initiative. "If you seek to harm or cheat Americans, we will find you, seize any assets and prosecute you to the fullest extent of the law."

In the Central District of California, federal prosecutors brought criminal charges against 10 defendants accused of defrauding government-funded healthcare programs or abusing their positions as medical professionals to illegally prescribe controlled substances.

The U.S. Attorney's Office for the Central District of California said five individuals were arrested in the greater Los Angeles area for allegedly participating in a scheme that involved submitting nearly $270 million in fraudulent claims to Medi-Cal for expensive prescription drugs.

Among those charged was Christina Mareik, 61, also known as Christina Marie Sanchez Hernandez, of Whittier.

Prosecutors allege Mareik helped facilitate fraudulent prescriptions that generated nearly $270 million in claims to Medi-Cal, which ultimately paid out more than $178 million.

According to prosecutors, the claims involved expensive drugs containing low-cost generic ingredients that were either not medically necessary or were never provided to the purported recipients.

Authorities said Mareik also sent thousands of fraudulent prescriptions to a co-conspirator and caused the submission of fraudulent prescriptions under her own name.

Mareik was arrested June 17 and charged with healthcare fraud.

The charges also include a San Fernando Valley man accused of operating hospice care companies that fraudulently billed Medicare approximately $27 million, according to prosecutors.

Prosecutors also charged Oren David Shachar, 59, of Van Nuys; Abraham Shin, 66, of Corona; and Jeannie Choi, 57, of Torrance.

The three defendants face a 16-count indictment alleging they conspired to defraud Medicare out of approximately $27 million.

The charges include conspiracy to commit healthcare fraud, healthcare fraud, aggravated identity theft, monetary transactions involving criminally derived property exceeding $10,000, and violations of the Anti-Kickback Statute.

Fox News Digital's Alexandra Koch contributed to this report.